Bacterial pyrogenic exotoxins as superantigens
نویسندگان
چکیده
منابع مشابه
Bacterial pyrogenic exotoxins as superantigens.
The recent discovery of the mode of interaction between a group of microbial proteins known as superantigens and the immune system has opened a wide area of investigation into the possible role of these molecules in human diseases. Superantigens produced by certain viruses and bacteria, including Mycoplasma species, are either secreted or membrane-bound proteins. A unique feature of these prote...
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Staphylococcal pyrogenic exotoxin (PE) types A and B were tested for their role in production of a scarlatiniform rash. The PEs elicited minimal skin reactions after intracutaneous injection into animals not presensitized to the toxins. In contrast, erythematous injection into animals not presensitized to the toxins. In contrast, erythematous and edematous rashes were produced after administrat...
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The inflammasomes are intracellular protein complexes that play an important role in innate immune sensing. Activation of inflammasomes leads to activation of caspase-1 and maturation and secretion of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18. In certain myeloid cells, this activation can also lead to an inflammatory cell death (pyroptosis). Inflammasome sensor proteins have ...
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3',5'-Cyclic adenosine monophosphate (cAMP) and 3',5'cyclic guanosine monophosphate (cGMP) are key second messengers for a wide variety of mammalian cellular processes. The natural occurrence of a third cyclic nucleotide, 3',5'-cyclic cytidine monophosphate (cCMP) had been discussed very controversially 30–35 years ago [1-3], but later, cCMP was identified unambiguously in various mammalian tis...
متن کاملNonspecific T-lymphocyte mitogenesis by pyrogenic exotoxins from group A streptococci and Staphylococcus aureus.
Group A streptococcal pyrogenic exotoxins types A, B, and C and staphylococcal pyrogenic exotoxin were shown to be potent nonspecific T-lymphocyte mitogens. Adherent cell populations did not significantly affect the nonspecific mitogenicity.
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ژورنال
عنوان ژورنال: Clinical Microbiology Reviews
سال: 1995
ISSN: 0893-8512,1098-6618
DOI: 10.1128/cmr.8.3.411